The Bode Lab
The Bode Lab

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February 21, 2020

We escaped the Mad Labs!

It was a frantic quest to resurrect the chained up, radioactive Professor (not Lars!) and break into the vault. But with comfortable 11 minutes left before the clock hits zero, triggering the complete annihilation of the lab, the Bode lab solved all puzzles and challenges as a team and escaped... Strobe lights, special effects and an undead Professor... The "Mad Lab: Resurrection" escape room was a great adventure...

February 18, 2020

New study out today in American Journal of Clinical Nutrition! - Associations between human milk oligosaccharides and growth in infancy and early childhood

Our earlier pilot studies in small cohorts of mothers and their infants followed up to 6 months of age in the US [Alderete et al. 2015] and Denmark [Larsson et al. 2019] found associations between specific HMOs and infant growth and body composition. Our new study found the very same HMOs being associated with length and weight in infancy and all the way to 5 years of age [Lagstrom et al. 2020].

 

In collaboration with Dr. Hanna Lagstrom and Dr. Samuli Rautava at the University of Turku in Finland, we analyzed the HMO composition in breast milk of over 800 mother-infant pairs from the Steps to healthy development of children (STEPS) study. Higher concentrations of the HMO 2'FL (2'-fucosyllactose) and lower concentrations of the HMO LNnT (lacto-N-neotetraose) were associated with higher length and weight in infancy and the differences persistent all the way to 5 years of age.

 

While associations do not establish causalities, it is striking that the very same HMOs are associated with infant growth in three independent cohorts. Our goal is to identify the underlying mechanisms, prove causalities, and eventually develop specific HMO blends targeted to assist growth and weight management in infants and potentially adults who have problems gaining weight or suffer from overweight and obesity.

 

Click Here to read the paper.

Click Here to read the UC San Diego press release.

Click Here to read the NIH/NICHD press release.

February 12, 2020

New study out today in PLOS ONE! - Human milk oligosaccharide 2’-fucosyllactose (2'FL) links feedings at 1 month to cognitive development at 24 months

Previous work in rodent models had shown that the human milk oligosaccharide 2'FL improves offspring learning and memory. In collaboration with Dr. Michael Goran's group at Children's Hospital Los Angeles we now show for the first time that higher 2'FL concentrations in mom's milk are indeed associated with baby's improved cognitive development at 2 years of age.

 

Future work will lead us to develop HMO-based interventions as well as novel human milk-based diagnostics to positively impact infant health and development.

 

Click Here to read the paper.

Click Here to read the full CHLA press release.

January 30, 2020

The Powers and Possibilities of Human Milk - LaunchBio's Larger Than Life Sciences event

Lars introduces the Bode lab and MOMI CORE and discusses the Powers and Possibilities of Human Milk with a highly engaged audience during the Larger Than Life Sciences event organized by LaunchBio and UC San Diego’s Office of Innovation and Commercialization.

 

Click for event photos!

January 27, 2020

Bode lab highlighted in San Diego County Medical Society magazine

Bode lab and MOMI CORE are highlighted in the January 2020 issue of the San Diego County Medical Society magazine.

 

"Promoting Mothers' Milk - The important role all physicians can play to improve infant and maternal health" by Nina C. Iwanaga (pages 12-15)

January 24, 2020

Lars gives 2020 Ved Londhe State-of-the-Art Lecture at WSPR conference in Carmel, California

January 17, 2020

Manuscript accepted for publication in American Journal of Clinical Nutrition

Our manuscript "Associations between human milk oligosaccharides and growth in infancy and early childhood" in collaboration with Dr. Hanna Lagstrom and Samuli Rautava at the University of Turku and Turku University Hospital in Finland has been accepted for publication in the American Journal of Clinical Nutrition.

86. Lagstrom H, Rautava S, Ollila H, Kaljonen A, Turta O, Makela J, Yonemitsu CGupta JBode L (2020) Associations between human milk oligosaccharides and growth in infancy and early childhood. Am J Clin Nutr (Accepted)

January 16, 2020

Jumbo Undertaking: Collaboration with San Diego Zoo Global featured in thisweek@ucsandiego

UC San Diego and San Diego Zoo Global collaborate to improve overall health and survival of elephant calves

 

“This is the start of a much bigger picture. Multiple other labs at UC San Diego are now involved in the emerging partnership, looking at milk fat composition, the metabolome, as well as the microbiome, not only in milk, but in all parts of the mother-milk-infant triad. This is a great example of how we break down the silos within and between institutions like UC San Diego and the San Diego Zoo Safari Park. It’s these non-traditional intersections where innovation and discoveries are made.”

January 14, 2020

Manuscript accepted for publication in PLOS ONE

Our manuscript "Human milk oligosaccharide 2'-fucosyllactose links feedings at 1 month to cognitive development at 24 months in infants of normal and overweight mothers" in collaboration with Dr. Michael Goran's group at Children's Hospital Los Angeles has been accepted for publication in the journal PLOS ONE.

 

Congratulations to Chloe Yonemitsu for her contribution to this project and yet another manuscript co-authorship.

 

85. Berger PK, Plows JF, Jones RB, Alderete TL, Yonemitsu C, Ryoo JH, Peterson BS, Bode L, Goran MI (2020) Human milk oligosaccharide 2'-fucosyllactose links feedings at 1 month to cognitive development at 24 months in infants of normal and overweight mothers. PLOS ONE (Accepted)

Dedicated to Research on Human Milk Oligosaccharides

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