The Bode Lab
The Bode Lab

Publications

58. Ruiz L, Espinosa-Martos I, García-Carral C, Manzano S, McGuire MK, Meehan CL, McGuire MA, Williams JE, Foster J, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Kvist L, Otoo GE, Lackey KA, Flores K, Pareja RG, Bode L, Rodriguez JM (2017) What’s normal? Immune profiling of human milk from healthy women living in different geographical and socio-economic settings. Frontier in Immunology (In Press)   [Research Article]

 

57. Williams JE, Price WJ, Shafii B, Yahvah KM, Bode L, McGuire MA, McGuire MK (2017) Relationships among microbial communities, maternal cells, oligosaccharides, and macronutrients in human milk. J Hum Lact (In Press)   [Research Article]

 

56. Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran KS, Nizet V, Bode L (2017) Human Milk Oligosaccharides Inhibit Growth of Group B Streptococcus. J Biol Chem (In Press)   [Research Article]

 

55. Aakko J, Kumar H, Rautava S, Wise A,  Autran C, Bode L, Isolauri E, Salminen S (2017) Human milk oligosaccharide categories define the microbiota composition in human colostrum. Beneficial Microbes (In Press)   [Research Article]

 

54. Autran CA, Kellman BP, Kim JH, Asztalos E, Blood AB, Hamilton Spence EC, Patel AL, Hou J, Lewis NE, Bode L (2017) Human milk oligosaccharide composition predicts risk of necrotizing enterocolitis in preterm infants. Gut (In Press)   [Research Article]

 

53. McGuire MK, Meehan CL, McGuire MA, Williams JE, Foster J, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Kvist LJ, Otoo GE, Brooker SL, Price WJ, Shafii B, Placek C, Lackey KA, Robertson B, Manzano S, Ruiz L, Rodriguez JM, Pareja R, Bode L (2017) What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically. Am J Clin Nutr (In Press)   [Research Article]

 

52. Daniels B, Coutsoudis A, Autran CA, Amundson Mansen K, Israel-Ballard K, Bode L (2017The effect of simulated flash heating pasteurisation and Holder pasteurisation on human milk oligosaccharidesPaediatrics and International Child Health (In Press)   [Research Article]

 

51. Moukarzel S, Bode L (2017) Human Milk Oligosaccharides and the Preterm Infant. Clin Perinatol 44(1):193-207   [Invited Review Article]

 

50. Seppo AE, Autran CA, Bode L, Järvinen KM (2017) Human milk oligosaccharides and development of cow’s milk allergy in infants. J Allergy Clin Immunol 139(2):708-711.e5.  [Research Article]

 

49. Bender JM, Li F, Martelly S, Byrt E, Rouzier V, Leo M, Tobin N, Pannaraj PS, Adisetiyo H, Rollie A, Santiskulvong C, Wang S, Autran C, Bode L, Fitzgerald D, Kuhn L, Aldrovandi GM (2016) Maternal HIV Infection Influences the Microbiome of HIV-Uninfected Infants. Science Translational Medicine 8(349):349ra100  [Research Article]

 

48. Bode L, Contractor N, Barile D, Pohl N, Prudden AR, Boons GJ, Jin YS, Jennewein S (2016) Approaches to overcome the limited availability of Human Milk Oligosaccharides: Challenges and opportunities for research and application. Nutr Rev. 74(10):635-44  [Review Article]

 

47. Holscher HD, Bode L, Tappenden KA (2016) Human Milk Oligosaccharides influence intestinal epithelial cell maturation in vitro. J Pediatr Gastroenterol Nutr. 64(2):296-301 [Research Article]

 

46.  Autran CA, Schoterman MHC, Jantscher-Krenn E, Kamerling JP, Bode L (2016) Sialylated galacto-oligosaccharides and 2’-fucosyllactose reduce necrotizing enterocolitis in neonatal rats. Br J Nutr 116(2):294-9 [Research Article]

 

45.  Alderete TL, Autran CA, Brekke BE, Knight R, Bode L, Goran MI, Fields DA (2015) Associations between human milk oligosaccharides and infant body composition in the first six months of life. Am J Clin Nutr 102(6):1381-8 [Research Article]

 

44. Bode L (2015) The functional biology of human milk oligosaccharides. Early Human Development. 91(11):619-22 [Invited Review Article]

 

43. Wahl A, Baker C, Spagnuolo RA, Stamper L, Fouda G, Permar S, Hinde K, Kuhn L, Bode L, Aldrovandi G, Garcia JV (2015) Breast milk of HIV-positive mothers has potent and species-specific in vivo HIV inhibitory activity. J Virol 89(21):10868-78 [Research Article]

 

42. Gonia S, Tuepker M, Heisel T, Autran CA, Bode L, and Gale CA (2015) Human Milk Oligosaccharides Inhibit Candida albicans Invasion of Premature Human Intestinal Epithelial Cells. J Nutr. 145(9):1992-8 [Research Article]

 

41. Chan SC, Bode L, Kim JH (2015) Galectin-3 binding protein in human preterm infant umbilical cord plasma. J Neonatal Perinatal Med. 8(2):99-104 [Research Article]

 

40.  Kuhn L, Kim HY, Hsiao L, Nissan C, Kankasa C, Mwiya M, Thea DM, Aldrovandi GM, Bode L (2015) Oligosaccharide composition of breast milk influences survival of uninfected children born to HIV-infected mothers in Lusaka, Zambia. J Nutr. 145(1):66-72  [Research Article]

 

39.  Etzold S and Bode L (2014) Glycan-dependent viral infection in infants and the role of human milk oligosaccharides. Curr Opin Virol. 7:101-7   [Invited Review Article]

 

38.  Bode L, McGuire M, Rodríguez JM, Geddes D, Hassiotou F, Hartmann PE, McGuire MK (2014) It’s Alive: Microbes and Cells in Human Milk and their Potential Benefits to Mother and Infant. Adv Nutr. 5(5):571-3   [Invited Review Article]

 

37.  Van Niekerk E, Autran CA, Nel DG, Kirsten GF, Blaauw R, Bode L (2014) Human Milk Oligosaccharides Differ between HIV-Infected and HIV-Uninfected Mothers and Are Related to Necrotizing Enterocolitis Incidence in Their Preterm Very-Low-Birth-Weight Infants. J Nutr. 144(8):1227-33   [Research Article]

 

36. Yu H, Lau K, Thon V, Autran CA, Jantscher-Krenn E, Xue M, Li Y, Sugiarto G, Qu J, Mu S, Ding L, Bode L, Chen X (2014) Novel Synthetic Disialyl Hexasaccharides Protect Neonatal Rats from Necrotizing Enterocolitis. Angew Chem Int Ed Engl. 53(26):6687-91.   [Research Article]

 

35.  Marx C, Bridge R, Wolf A, Rich W, Kim JH, Bode L (2014) Human Milk Oligosaccharide composition differs between Donor Milk and Mother’s Own Milk in the NICU. J Hum Lact. 30(1):54-61   [Research Article]

 

34.  Manthey CF, Autran CA, Eckmann L, Bode L (2014) Human Milk Oligosaccharides protect against enteropathogenic E.coli attachment in vitro and colonization in suckling mice. J Pediatr Gastroenterol Nutr. 58(2):167-70   [Research Article]

 

33.  Lin AE, Autran CA, Espanola SD, Bode L, Nizet V (2014) Human Milk Oligosaccharides Protect Bladder Epithelial Cells Against Uropathogenic Escherichia coli Invasion and Cytotoxicity. J Infect Dis. 209(3):389-98   [Research Article]

 

32.  Chan CS, Kim HT, Autran C, Kim JH, Sinkala M, Kankasa C, Mwiya N, Thea DM, Aldrovandi GM, Kuhn L, Bode L (2013) Human milk Galectin-3 Binding Protein (Gal3BP)  and breastfeeding-associated  HIV transmission. Pediatr Infect Dis J. 32(12):e473-5   [Research Article]

 

31.  Meier P and Bode L (2013) Health, Nutrition and Cost Outcomes of Human Milk Feedings for Very Low Birthweight Infants. Adv Nutr  4(6):670-1   [Invited Review Article]

 

30.  Jantscher-Krenn E, Marx C, Bode L (2013) Human Milk Oligosaccharides are differentially metabolized in neonatal rats. Br J Nutr. 110(4):640-50   [Research Article]

 

29.  Preuss J, Richardson AD, Pinkerton AB, Hedrick MP, Sergienko E, Rahlfs S, Becker K, Bode L (2012) Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. J Biomol Screen. 17(6):738-51   [Research Article]

 

28.  Preuss J, Maloney P, Peddibhotla S, Hedrick MP, Hershberger P, Gosalia P, Milewski M, Li YL, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth GP, Diwan J, Chung TDY, Jortzik E, Rahlfs S, Becker K, Pinkerton AB, Bode L (2012) Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro. J Med Chem. 55:7262-72   [Research Article]

 

27.  Maloney P, Hedrick M, Peddibhotla S, Hershberger P, Milewski M, Gosalia P, Li L, Preuss J, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergieko E, Salanawil S, Stonich D, Su Y, Dahl R, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth GP, Diwan J, Chung TDY, Pinkerton AB, Bode L, Becker K (2012) A 2nd Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH) [ML304]. Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012 Mar 28 [updated 2013 Mar 14]  [NIH Probe Report]

 

26.  Bode L, Kuhn L, Kim HY, Hsiao L, Nissan C, Sinkala M, Kankasa C, Mwiya M, Thea DM, Aldrovandi GM (2012) Human Milk Oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding. Am J Clin Nutr. 96:831-9   [Research Article]

 

25.  Jantscher-Krenn E and Bode L (2012) Structure-Function Relationships of Human Milk Oligosaccharides. Adv Nutr. 3:383S-91S   [Invited Review Article]

 

24.  Maloney P, Hedrick M, Peddibhotla S, Hershberger P, Milewski M, Gosalia P, Li L, Preuss J, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Salanawil S, Stonich D, Su Y, Dahl R, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth G, Diwan J, Chung TDY, Pinkerton AB, Bode L, Becker K (2012) A selective inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH) [ML276]. Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2011 Dec 16 [updated 2013 Mar 7]  [NIH Probe Report]

 

23.  Bode L (2012) Human Milk Oligosaccharides: Every baby Needs a Sugar Mama. Glycobiology 22: 1147-62 - doi: 10.1093/glycob/cws074   [Invited Review Article]

 

22.  Hunt KM, Preuss J, Nissan C, Davlin C, Williams J, Richardson A, McGuire MK, Bode L, McGuire MA (2012) Human milk oligosaccharides enhance the growth of Staphylococci. Appl Environ Microbiol 78: 4763-70 - doi: 10.1128/​AEM.00477-12   [Research Article]

 

21.  Preuss J, Hedrick M, Sergienko E, Pinkerton A, Marx C, Jortzik E, Ralphs S, Becker K, Bode L (2012) High-throughput screening for small-molecule inhibitors of Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase. J Biomol Screen 17: 738-51 - doi: 10.1177/1087057112442382   [Research Article]

 

20.  Jantscher-Krenn E, Lauwaet T, Bliss LA, Reed SL, Gillin FD, Bode L (2012) Human Milk Oligosaccharides reduce Entamoeba histolytica attachment and cytotoxicity in vitro. Br J Nutr. 108(10):1839-46 - doi:10.1017/S0007114511007392   [Research Article]

 

19.  Bode L and Jantscher-Krenn E (2012) Human Milk Oligosaccharides and their potential benefits for the breast-fed neonate. Minerva Pediatr. 64:83-99   [Invited Review Article]

 

18.  Jantscher-Krenn E, Zherebtsov M, Nissan C, Goth K, Guner YS, Naidu N, Choudhury BP, Grishin AV, Ford HR, Bode L (2011) The Human Milk Oligosaccharide Disialyllacto-N-tetraose prevents Necrotizing Enterocolitis in neonatal rats. GUT. 61(10):1417-25 - doi:10.1136/gutjnl-2011-301404   [Research Article]

 

17.  Jortzik E, Mailu BM, Preuss J, Fischer M, Bode L, Rahlfs S, Becker K (2011) Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum. Biochem J 436:641-50   [Research Article]

 

16.  Bode L (2009) Human Milk Oligosaccharides: Prebiotics and Beyond.  Nutr Rev 67: S183-91   [Invited Review Article]

 

15.  Hong P, Ninonuevo M, Lee B, Lebrilla C, Lee B, Bode L (2008) Human Milk Oligosaccharides reduce HIV-1-gp120 binding to DC-SIGN.   Br J Nutr 101: 482-486   [Research Article]

 

14.  Higashidani A, Bode L, Nishikawa A, Freeze HH (2008) Exogenous Mannose does not raise steady state mannose-6-phosphate pools of normal or N-glycosylation-deficient human fibroblasts. Mol Genet Metab 96: 268-272   [Research Article]

 

13.  Ninonuevo M, Bode L (2008) Infant formula Oligosaccharides opening the gates (for speculation). Invited commentary,   Pediatr Res 64: 8-10   [Invited Commentary]

 

12.  Liem YS, Bode L, Freeze HH, Leebeek FWG, Wilson JHP (2008) Heparin Reverses Protein-Losing Enteropathy in a Patient with Congenital Disorder of Glycosylation type 1b.   Nat Clin Pract Gastroenterol Hepatol 5: 220-224   [Research Article]

 

11.  Bode L, Salvestrini C, Park PW, Li JP, Esko J, Yamaguchi Y, Murch S, Freeze HH (2008) Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function.   J Clin Invest 118: 229-238   [Research Article]

 

10.  Tanumihardjo SA, Anderson C, Kaufer-Horwitz M, Bode L, Emenaker NJ, Haqq AM, Satia JA, Silver HJ, Stadler DD (2007) Poverty, Obesity and Malnutrition: An International Perspective Recognizing the Paradox.   J Am Diet Assoc. 107: 1966-7.   [Invited Commentary]

 

9.  Greig KT, Antonchuk J, Metcalf D, Morgan PO, Krebs DL, Zhang JG, Hacking DF, Robb L, de Graaf C, Bahlo M, Nicola NA, Nutt SL, Kranz C, Bode L, Freeze HH, Alexander WS, Hilton DJ, Kile BT (2007) Global reductions in sugar nucleotide synthesis caused by Pgm3 deficiency result in specific hematopoietic and developmental defects.   Mol Cell Biol 27: 5849-5859   [Research Article]

 

8.  Bode L (2006) Recent advances on structure, metabolism, and function of human milk oligosaccharides.  J Nutr 136: 2127-2130   [Review Article]

 

7.  Bode L and Freeze HH (2006) Applied glycoproteomics - Approaches to study genetic- environmental collisions causing protein-losing enteropathy.  Biochim Biophys Acta 1760: 547-559   [Review Article]

 

6.  Bode L, Murch S, Freeze HH (2006) Heparan sulfate plays a central role in a dynamic in vitro model of protein-losing enteropathy.   J Biol Chem 281: 7809-7815   [Research Article]

 

5.  DeRossi C*, Bode L*, Eklund EA, Zhang F, Davis JA, Westphal V, Wang L, Borowsky AD, Freeze HH (2006) Ablation of mouse phosphomannose isomerase (Mpi) causes mannose-6-phosphate accumulation, toxicity, and embryonic lethality.   J Biol Chem 281: 5916-5927 [*contributed equally] [Research Article]

 

4.  Bode L, Eklund EA, Murch S, Freeze HH (2005) Heparan sulfate depletion amplifies TNFalpha-induced protein leakage in an in vitro model of protein-losing enteropathy.   Am J Physiol Gastrointest Liver Physiol 288: G1015-23   [Research Article]

 

3.  Bode L, Muhly-Reinholz M, Pohlentz G, Seeger W, Kunz C, Rudloff S (2004) Human milk oligosaccharides as inhibitors of monocyte and lymphocyte adhesion to endothelial cells. Thromb Haemost 92: 1402-10   [Research Article]

 

2.  Bode L, Rudloff S, Kunz C, Strobel S, Klein N (2004) Human milk oligosaccharides reduce platelet-neutrophil complex-formation leading to a decrease in neutrophil beta 2 integrin expression.   J Leukoc Biol 76: 820-6   [Research Article]

 

1. Bode L, Mank M, Beermann C, Kohn G, Boehm G (2004) Differences in the fatty acid composition of human milk and bovine milk gangliosides.   J Nutr 134: 3016-20 [Research Article]
 

Dedicated to Research on Human Milk Oligosaccharides

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